Eflornithine m salt Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3

ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts

Epub 2011 Jun 25

Smiles: CN1C=C(C=N1)C1C=CC(=CC=1)C1=CN=CC(Cl)=C1N1CCC2(CCNC2=O)CC1

Eflornithine m salt Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3Eflornithine, also known as Difluoromethylornithine, is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of