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Furthermore, our data reinforce the compartmentalized nature of Fe-S cluster synthesis itself, as analysis of extramitochondrial Fe-S protein stability indicated varied sensitivity towards cysteine limitation that was not seen with mitochondrial proteins

A broader 2020 review by Sikiric and colleagues in Gut and Liver frames the compound's proposed GI activity within Robert's cytoprotection and organoprotection model the longstanding physiological framework describing how the gastric mucosa protects itself against injury

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Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al