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GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S and DNA-PK

GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S and DNA-PK

Name: GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S and DNA-PK
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SKU: 58947463915
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GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S and DNA-PKGSK591, also known as EPZ015866 and GSK3203591, CAS No. 1616391 87 7, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5 MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z 138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. Product information CAS

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Description

and DNA-PK

CX-4945 (Silmitasertib)

InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11

compound list : BAY-87-2243

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