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They are smaller than proteins but large enough to carry specific biological messages

This depends on the frequency and severity of vomiting

Future research must prioritize definitive comparative cardiovascular outcome trials and rigorous real-world analyses to address current observational limitations and fully elucidate long-term comparative effectiveness

For the SURPASS-CVOT emulation (tirzepatide vs dulaglutide), the hazard ratio for MACE was 0.83 (95% CI, 0.691.01) compared with 0.92 (95% CI, 0.831.01) in the trial, satisfying all concordance criteria