Neon drop · Free ship $75+ · Enter the grid
Login Register
Signal · Product Feed
IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis
IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis
IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis
IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis

IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis

SKU: 86003539549

4.7
SEK35.00 SEK83.00

Pay in 4 interest-free payments of $8.75 Learn more

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 6 - Aug 11

Live Spec

IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosisIOX4, CAS No. 1154097 71 8, is a potent and selective PHD2 inhibitor with IC50 ~1. 6 nM. It inhibits PHD2 via binding to the 2OG binding site, displays >1, 000 fold selectivity for PHD2 over other 2OG dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF 1 levels in cells (IC50 ~5. 6 11. 7 M) and inducing HIF 1 and HIF 2 expression in mice. The

Store: lifelines-uk.org.uk · Domain: lifelines-uk.org.uk

Description

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant

75 µM (TOPflash assay)

5 mg/kg dissolved in 0

IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosisIOX4, CAS No. 1154097 71 8, is a potent and selective PHD2 inhibitor with IC50 ~1. 6 nM. It inhibits PHD2 via binding to the 2OG binding site, displays >1, 000 fold selectivity for PHD2 over other 2OG dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF 1 levels in cells (IC50 ~5. 6 11. 7 M) and inducing HIF 1 and HIF 2 expression in mice. The

Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy

You may also like

recommand products