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R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 10(485):eaak9916

R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 10(485):eaak9916

Name: R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 10(485):eaak9916
Brand: lifelines-uk.org.uk
SKU: 90271538448
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R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 10(485):eaak9916Bemcentinib, also known as BGB 324 or R428, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl dependent events, including Akt

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Description

10(485):eaak9916

Mazurkiewicz M

Formula: C49H60N4O14

InChi: InChI=1S/C11H9NO2S2/c13-16-6-5-14-12-11(16)10-7-8-3-1-2-4-9(8)15-10/h1-4

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