EHop-016 at (LY450139) 3 μM) induces 50% degradation

3 μM) induces 50% degradation of endogenous SGK3 within 2 hours

(43):5438-40

is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner

BRD0539 does not interfere with the SpCas9:gRNA interaction

EHop-016 at (LY450139) 3 μM) induces 50% degradationEHop 016 is a novel potent and selective inhibitor of RAC. EHop 016 inhibits Rac activity in the MDA MB 435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity. The IC(50) of 1. 1 M for Rac inhibition by EHop 016 is ~ 100 fold lower than for NSC23766. EHop 016 is specific for Rac1 and Rac3 at concentrations of < 5 M. At higher concentrations, EHop 016 inhibits the close homolog Cdc42. EHop 016 also inhibits the Rac