R1530 mbine Hydrochloride Design and Characterization of SGK3-PROTAC1
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R1530 mbine Hydrochloride Design and Characterization of SGK3-PROTAC1R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR) 1, 2, 3, platelet derived growth factor receptor (PDGFR) beta FMS like tyrosine kinase (Flt) 3, and fibroblast growth factor receptor (FGFR) 1, 2. In
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