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Figure 8 3.5 Chronic fatigue syndrome (CFS) A growing body of clinical evidence shows that the gut microbiota plays a critical role in CFS, with consistently observed reductions in butyrate-producing bacteria and enrichment of Enterobacteriaceae , together with frequent depletion of anti-inflammatory taxa such as Faecalibacterium (Knig et al., 2021

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Acknowledgements This research was partially supported by NSF grants DMS-0616710(MR, HFN) and EF-1038593(HFN, MR) and NIH grant R01 ES019876 (D

However, the strategy should also be adaptive and responsive to the emerging data