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Bacterial components in the synovial tissue of patients with advanced rheumatoid arthritis or osteoarthritis: analysis with gas chromatography-mass spectrometry and pan-bacterial polymerase chain reaction

An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies

A significant percentage of corticotroph adenomas harbor somatic mutations in USP8, and a germline mutation case have also been described and can develop Cushings disease (147,150,151)

These approaches encompass various mechanisms, including regulating iron homeostasis, inhibiting lipid peroxidation, modulating GPX4 and FSP1 pathways, and utilizing a range of novel compounds and natural products ( Figure 4 )