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The goal will be to address the risk of malnutrition and the loss of lean muscle mass while on the GLP-1 therapy and to avoid or limit weight rebound after the therapy

Oxidative stress induced by mitochondrial and non-mitochondrial ROS and inflammation has been reported as the mechanism underlying insulin resistance ( Excessive ROS production is known to suppress antioxidant defense systems and physical exercise training has been shown to upregulate antioxidant defense mechanisms in several tissues and metabolic disorders ( The drug metabolizing enzymes, cytochrome P450 2E1 and 3A4 were also found to be activated in the liver and kidney of diabetic GK rats

Curcumin, the main bioactive compound found in Curcuma longa (turmeric), has been utilized in traditional medicine for more than 4,000 years and is well known for its therapeutic benefits [37, 38]

The + 4-oxidation state of Mn in MnO imparts strong oxidative properties, enabling its responsiveness to reducing agents like GSH, allowing it to be rapidly reduced and degraded by GSH