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A typical semaglutide titration: Weeks 1-4: 0.25mg once weekly Weeks 5-8: 0.5mg once weekly Weeks 9-12: 1.0mg once weekly Weeks 13-16: 1.7mg once weekly Week 17 onward: 2.4mg once weekly (maximum maintenance dose) A typical tirzepatide titration: Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5.0mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Week 17 onward: 12.5-15mg once weekly (if needed) Some researchers find their optimal dose well below the maximum