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1 Introduction Schizophrenia (SZ) is a chronic brain disorder characterized by genetic heterogeneity and neuropathological alterations, with high mortality rates ( Current evidence from genetics, molecular neuropathology, and clinical studies underscores the importance of immune factors in both the pathogenesis and treatment of schizophrenia ( Figure 1 )

Stress can alter the production of peptide hormones and cytokines, contributing to inflammation and immune dysfunction

Food intake in lean and obese mice after peripheral administration of glucagon-like peptide-2

One depends on the GLP-1 receptor mediated action with inotropic, glucose uptake stimulating, and ischemic preconditioning effects, and secondly that the GLP-1 receptor independent pathway causes vasodilatation that is mediated by nitric oxide 5