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However, it has also been reported that although deletion of hepatocyte Dpp4 expression abolished the obesity-induced rise in circulating DPP-4 and was associated with reduced levels of proinflammatory cytokines in hepatocytes and adipose tissue, levels of circulating soluble DPP-4 per se did not correlate with tissue or systemic inflammation (82)

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Cytosolic double-stranded DNA as a damage-associated molecular pattern induces the inflammatory response in rat pancreatic stellate cells: a plausible mechanism for tissue injury-associated pancreatitis

Am J Physiol Regul Integr Comp Physiol2006 Nov;291(5):R1283-7