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Semaglutide is available in both injectable and oral forms, but there are some key differences in pricing and accessibility that patients should consider

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Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)

Calley believes that we should, instead, focus on a more functional approach to clean up the fish tank first (remove ultra-processed foods from kids diets, encourage exercise, etc), and if that doesnt work, move toward more intensive interventions like weight loss medication